Biomimetic oxygen delivery nanoparticles for enhancing photodynamic therapy in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is a kind of aggressive with high rate metastasis, poor overall survival time, and low response to targeted therapies. To improve the therapeutic efficacy overcome drug resistance TNBC treatments, here we developed cell membrane-coated oxygen delivery nanoprobe, CCm–HSA–ICG–PFTBA, which can hypoxia at tumor sites enhance photodynamic therapy (PDT), resulting in relieving growth xenografts. Results The size CCm–HSA–ICG–PFTBA was 131.3 ± 1.08 nm. vitro 1 O 2 ROS concentrations group were both significantly higher than those other groups ( P < 0.001). In vivo fluorescence imaging revealed that best time window 24 h post-injection CCm–HSA–ICG–PFTBA. Both 18 F-FMISO PET ex immunofluorescence staining results exhibited improved For PDT treatment, volume weight NIR smallest among all decreased compared untreated 0.01). No obvious biotoxicity observed by injection till 14 days. Conclusions By using solubility perfluorocarbon (PFC) homologous targeting ability membranes, target tissues, mitigate microenvironment, Furthermore, HSA, ICG, PFC are FDA-approved materials, render nanoparticles highly biocompatible potential for clinical translation treatment patients.